Hi there 👋

I'm a recently graduated bioinformatics PhD student from the labs of Prof Pietro Fratta & Dr Maria Secrier at UCL. I mainly focus on bioinformatic analysis of alternative polyadenylation (APA) in amyotrophic lateral sclerosis (ALS) with RNA-seq data. Generally very interested in using sequencing approaches to understand how RNA-binding proteins influence the transcriptome and taking any opportunity to build Snakemake pipelines!

Currently working on:

• Developing improved methods for identifying, quantifying and assessing differential usage of polyA sites from bulk RNA-seq data (watch this space!)

Previous major projects:

• Analysis of APA dysregulation in ALS - Developed analysis pipelines in Snakemake (e.g. PAPA, QAPA_snakemake, bulk_polya_tail_reads, bedops_parse_star_junctions, rna_seq_single_steps) and analysis code (tdp43-apa, thesis)
• APAeval - a community project to develop a framework for reproducible benchmarking of bioinformatic algorithms and assess the performance of tools that identify and/or quantify polyA sites from bulk RNA-seq data.